Whitepaper
Draft v0.1 April 2024
Creatine monohydrate (CM) is a popular dietary supplement often used by athletes and individuals engaged in resistance training. It is known for its potential to enhance physical performance and increase lean mass. The body naturally produces creatine, primarily in the liver, kidneys, and pancreas, and it's also found in foods like meat and fish. Creatine supplements, like CM, are used to increase the body's stores of phosphocreatine, which can then be used to produce more ATP, the body's primary energy molecule.
Creatine supplementation has been extensively researched for its effects on athletic performance and muscle physiology. It is commonly used by athletes to increase lean mass, improve muscular power and strength, and promote skeletal muscle adaptations. A study on female collegiate dancers showed that CM supplementation led to a significant increase in total body water and lean mass.
Creatine supplementation has also been explored in the context of medical rehabilitation. It has been investigated as a supplemental agent to mitigate the loss of muscle mass and function in a variety of acute and chronic conditions affecting the musculoskeletal, cardiopulmonary, and nervous systems. While some findings are encouraging, showcasing creatine’s potential efficacy as a supplemental agent via preservation of muscle mass, strength, and physical function, the results are not consistent.
In a 2-year, randomized, placebo-controlled trial, creatine supplementation was investigated for its potential to improve bone health in older, postmenopausal women. The study found that while lean mass and appendicular skeletal muscle mass increased throughout the intervention, creatine did not have an additive effect.
The unique physiological and hormonal considerations of women, particularly in the context of aging and changes such as menopause, make creatine supplementation a topic of great
interest beyond athletic and rehabilitation settings. For premenopausal women, creatine offers potential benefits that could preempt the decline in muscle mass and bone density typically accelerated by menopause. By supporting muscle mass and strength before the onset of menopause, creatine can lay a foundation that might mitigate the rapid changes that occur when estrogen levels begin to decrease.
For postmenopausal women, maintaining muscle mass and strength is not just a matter of physical aesthetics but also a crucial aspect of preventing osteoporosis and enhancing overall health and mobility. This concern is heightened by the natural decline in estrogen levels, which significantly impacts bone density and muscle mass.
Research into creatine's impact on women's health, especially for those who are premenopausal and postmenopausal, suggests that it may offer significant benefits in slowing down the progression of age-related muscle loss and enhancing strength. This, coupled with its potential to indirectly support bone density through increased muscle mass, highlights a promising area for further research and application. It is essential for women considering creatine supplementation to understand these potential benefits and weigh them against the possible side effects, consulting healthcare providers to tailor a regimen that acknowledges their unique health trajectories and nutritional needs.
While creatine is generally considered safe for use, some potential side effects have been reported. These include gastrointestinal issues, such as stomach cramping, nausea, diarrhea, and dehydration. It's also been suggested that creatine supplementation should not be used by individuals with preexisting renal disease, and that risk should be evaluated before and during any supplementation period.
The majority of clinical studies fail to find an increased incidence of side effects with creatine supplementation, and studies have not found clinically significant deviations from normal values in renal, hepatic, cardiac, or muscle function. However, it's important to note that most of the health claims present in the labeling of CM products do not comply with the criteria established by scientific reference documents. Therefore, it's crucial for consumers to critically evaluate the information provided on these products and consult with healthcare professionals before starting any supplementation regimen.
Creatine monohydrate is a popular and widely researched supplement with potential benefits for athletic performance, cognitive function, and overall health. While it is generally considered safe and well-tolerated, it is essential to follow proper dosing guidelines and maintain adequate hydration to minimize potential side effects. Especially for women, who may experience unique
health benefits from creatine, it's crucial to consult healthcare professionals before starting any supplementation regimen. Given its potential to support muscle mass and bone health, creatine supplementation can be particularly important for women as they navigate the physiological changes associated with different life stages, ensuring safety and efficacy in the context of their specific health needs.
Jäger R, Purpura M. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids. 2011;40(5):1369-1383. doi:10.1007/s00726-011-0874-6
Mielgo-Ayuso J, Calleja-González J, Urdampilleta A, León-Guereño P, Córdova A, Caballero-García A. Analysis of health claims regarding creatine monohydrate present in commercial communications for a sample of European sports foods supplements. Public Health Nutr. 2021;24(2):330-339. doi:10.1017/S1368980020002939
Nag S. Trends in Creatine Supplementation for Athletes: A Systematic Review. 2023. https://api.semanticscholar.org/CorpusID:261948155
Candow DG, Forbes SC, Chilibeck PD, Cornish SM, Antonio J, Kreider RB. The Application of Creatine Supplementation in Medical Rehabilitation. Nutrients. 2021;13(6):1763. doi:10.3390/nu13061763
Galvan E, Walker DK, Simbo SY, et al. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. J Int Soc Sports Nutr. 2016;13:12. doi:10.1186/s12970-016-0124-0
P. Chilibeck et al. "Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women.." Medicine and science in sports and exercise, 47 8 (2015): 1587-95 . https://doi.org/10.1249/MSS.0000000000000571.
D. Lobo et al. "Effects of long-term low-dose dietary creatine supplementation in older women." Experimental Gerontology, 70 (2015): 97-104.
https://doi.org/10.1016/j.exger.2015.07.012.